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NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
R&D / Tech · National Institutes of Health · Nationwide
The Parent SBIR (R43/R44) grant is a federal, non-repayable funding opportunity from the NIH, CDC, and FDA that helps U.S. small businesses conduct research and development to bring scientific innovations to market, with applications open nationwide until April 5, 2027.
The Parent SBIR (R43/R44) grant is a federal funding opportunity offered through the Small Business Innovation Research (SBIR) program, a joint initiative involving the National Institutes of Health (NIH), CDC, and FDA. This grant is designed to help United States small business concerns (SBCs) move scientific innovations from early-stage feasibility studies into full research and development (R&D) needed to create a commercial product.
The R43 phase typically supports initial feasibility work, while the R44 phase funds more advanced development once feasibility is demonstrated. This particular opportunity is 'Clinical Trial Optional,' meaning applicants may propose projects that include a clinical trial component, but it is not required.
This grant matters to small-business owners in the research and technology space because it provides non-dilutive funding — meaning businesses do not give up equity — to pursue scientific and technical innovation with commercial potential. It is particularly relevant for small businesses developing biomedical, health-related, or scientific technologies that could benefit from federal R&D support.
The grant is open to small businesses in all U.S. states, but foreign organizations and non-U.S. components of U.S. organizations are not eligible to apply. Specific award amounts, funding floors, and ceilings were not provided in the available data, so applicants should confirm exact funding levels directly through the official source. The deadline listed for this opportunity is April 5, 2027. Because SBIR opportunities like this one often have detailed technical and administrative requirements, prospective applicants are strongly encouraged to review the full Notice of Funding Opportunity (NOFO) and eligibility criteria at the official application link before beginning the process.
Who qualifies
How to apply
Questions people ask
Is this a grant or a loan?
It is a grant, funded through the SBIR program.
Do I have to repay this money?
No, SBIR grants do not require repayment.
Who is eligible to apply?
Only U.S. small business concerns (SBCs) as defined by the SBA are eligible; foreign organizations are not.
How much funding can I get?
The specific award floor and ceiling were not provided; confirm exact amounts at the official source.
What is the application deadline?
The deadline listed is April 5, 2027.
Where do I apply?
You can apply through the official Grants.gov listing at https://www.grants.gov/search-results-detail/359671.
Which agencies are involved?
The National Institutes of Health (NIH), along with CDC and FDA, are involved in this SBIR opportunity.
What does this grant fund?
It funds feasibility studies and R&D to help small businesses bring scientific innovations to market.
Is a clinical trial required?
No, this opportunity is 'Clinical Trial Optional.'
Can foreign businesses apply?
No, non-domestic entities and non-U.S. components of U.S. organizations are not eligible.
Are there state restrictions?
No, businesses from all U.S. states are eligible to apply.
Is the award taxable?
This information was not provided; confirm at the official source.
What phase does this funding cover?
It covers R43 (feasibility) and R44 (full R&D) phases of the SBIR program.
Where can I find more details?
Full details are available in the NOFO and at the official Grants.gov link provided.
Opportunity number: PA-27-100. Source: grants.gov. GetFundedUSA is independent and not affiliated with National Institutes of Health; always confirm current deadlines, amounts and eligibility on the sponsor's own page before applying.