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NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
R&D / Tech · National Institutes of Health · Nationwide
The NIH SBIR Phase IIB Strategic Breakthrough Award is a federal grant from the National Institutes of Health that provides additional research and development funding to U.S. small businesses that previously completed an NIH SBIR or STTR Phase II award, helping bridge the gap to commercialization.
The NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent R44, Clinical Trial Optional) is a federal grant program administered by the National Institutes of Health. It is designed to bridge the funding gap that often occurs between the end of an SBIR or STTR Phase II award and the point at which a technology becomes ready for commercialization.
This award provides additional funding for later-stage research and development to small business concerns that have already completed an NIH SBIR or STTR Phase II award. It is intended for businesses continuing work on a previously funded project rather than starting new research, and it is submitted as a Renewal or Resubmission ("Type 2") application.
Funding is provided as a grant, meaning it does not need to be repaid, though it comes with reporting and compliance requirements typical of federal awards. The program is open to eligible small businesses located anywhere in the United States, and there is no state restriction on eligibility.
Only U.S.-based small business concerns may apply. Foreign organizations, and non-U.S. components of U.S. organizations, are not eligible. Unfunded international collaborations may be permitted under certain conditions described in the NIH Grants Policy Statement.
This grant may matter to a small-business owner who previously received NIH SBIR or STTR Phase II funding and needs continued financial support to move a technology closer to market. Because eligibility is narrowly tied to prior NIH Phase II funding and specific submission timing, applicants should carefully review the full Notice of Funding Opportunity (NOFO) for eligibility details, award amounts, and submission windows before applying. Amounts, specific dates for the six eligible due dates, and other award specifics should be confirmed directly at the official source listed.
Who qualifies
How to apply
Questions people ask
Is this a grant or a loan?
It is a grant, funded through NIH's SBIR program; it does not need to be repaid.
Do I have to pay this money back?
No, this is a grant, not a loan, but funds must be used according to the award terms.
Who is eligible to apply?
Only U.S. small business concerns that previously received an NIH SBIR or STTR Phase II award may apply, within the first six due dates after their prior budget period ends.
Can foreign companies apply?
No, foreign organizations and non-U.S. components of U.S. organizations are not eligible.
How much funding can I receive?
The specific award amount is not stated in the available data; confirm at the official source.
What is the deadline to apply?
The listed deadline is April 5, 2029, but applicants should confirm specific due dates in the NOFO.
Where do I apply?
Applications are submitted through the official listing at https://www.grants.gov/search-results-detail/359758.
What does this grant fund?
It funds later-stage research and development for projects that previously received NIH SBIR or STTR Phase II funding, bridging the gap to commercialization.
Can I apply for a brand-new project?
No, this award only supports continuation of a previously funded NIH Phase II SBIR/STTR project.
Is this a state or federal program?
It is a federal program administered by the National Institutes of Health.
Are there state restrictions on eligibility?
No, businesses from all U.S. states are eligible, provided other criteria are met.
Is the award taxable?
This is not addressed in the available data; confirm at the official source.
How many times can I receive this award?
Only one Phase IIB Strategic Breakthrough award is allowed per project.
Opportunity number: PA-27-101. Source: grants.gov. GetFundedUSA is independent and not affiliated with National Institutes of Health; always confirm current deadlines, amounts and eligibility on the sponsor's own page before applying.